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A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1978,
Cytogenetics and cell genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1977,
Cytogenetics and cell genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
March 1976,
Human genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1973,
Cytogenetics and cell genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
December 1977,
Human genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
June 1972,
Science (New York, N.Y.),
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1983,
Human genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1997,
Cytogenetics and cell genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1979,
Annals of human genetics,
T B Shows, and
J A Brown, and
R L Eddy, and
M G Byers, and
L L Haley, and
E S Cooper, and
A P Goggin
January 1998,
Cytogenetics and cell genetics,
