BIOMAT Database Logo BIOMAT Database Logo

Detection of preservatives in pharmaceutical and cosmetic products using agar gel electrophoresis. 1978

K E Moore, and R J Stretton

A method is described using high voltage agar gel electrophoresis for the separation and microbiological detection of preservatives in pharmaceutical and cosmetic products. The positions of the preservatives were detected as zones of inhibition of a test organism within the nutrient agar gel and can be characterised by their migration, shape and presence of a halo. A wide range of preservatives commonly used in pharmaceutical and cosmetic preparations could be detected in low concentrations. The method however was not suitable for certain volatile preservatives and many primarily antifungal compounds could be detected above their use concentration.

UI MeSH Term Description Entries
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D010592 Pharmaceutic Aids Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES. Aids, Pharmaceutic,Aids, Pharmaceutical,Pharmaceutical Aids
D011310 Preservatives, Pharmaceutical Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants. Pharmaceutic Aids (Preservatives),Pharmaceutic Preservative,Pharmaceutic Preservatives,Pharmaceutical Preservative,Pharmaceutical Preservatives,Preservative, Pharmaceutic,Preservative, Pharmaceutical,Preservatives, Pharmaceutic
D003358 Cosmetics Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995) Personal Care Products,Care Product, Personal,Care Products, Personal,Personal Care Product,Product, Personal Care,Products, Personal Care
D004587 Electrophoresis, Agar Gel Electrophoresis in which agar or agarose gel is used as the diffusion medium. Electrophoresis, Agarose Gel,Agar Gel Electrophoresis,Agarose Gel Electrophoresis,Gel Electrophoresis, Agar,Gel Electrophoresis, Agarose

Related Publications

K E Moore, and R J Stretton
Detection of paraproteins in agar gel electrophoresis.
October 1967, Clinica chimica acta; international journal of clinical chemistry,
K E Moore, and R J Stretton
Antimicrobial agents as preservatives in pharmaceutical and cosmetic products. Agents as preservatives in eye-drops and contact lens solutions.
June 1978, The Journal of applied bacteriology,
K E Moore, and R J Stretton
[Agar gel electrophoresis].
February 1966, Rinsho byori. The Japanese journal of clinical pathology,
K E Moore, and R J Stretton
[Micromethod of electrophoresis in agar-agar gel].
January 1959, Voprosy meditsinskoi khimii,
K E Moore, and R J Stretton
Antimicrobial agents as preservatives in pharmaceutical and cosmetic products. Introduction: The scope of the problem.
June 1978, The Journal of applied bacteriology,
K E Moore, and R J Stretton
Determination of preservatives in cosmetic products. I. Thin-layer chromatographic procedure for the identification of preservatives in cosmetic products.
December 1987, Journal of chromatography,
K E Moore, and R J Stretton
WASHING OF AGAR FOR AGAR GEL ELECTROPHORESIS.
April 1964, Clinica chimica acta; international journal of clinical chemistry,
K E Moore, and R J Stretton
[Zone electrophoresis in agar gel].
January 1956, Arbeiten aus dem Paul-Ehrlich-Institut, dem Georg-Speyer-Haus und dem Ferdinand-Blum-Institut zu Frankfurt a.M,
K E Moore, and R J Stretton
[PREPARATORY ELECTROPHORESIS IN AGAR GEL].
May 1963, Ceskoslovenska farmacie,
K E Moore, and R J Stretton
Antimicrobial agents as preservatives in pharmaceutical and cosmetic products. Antimicrobial agents in single- and multi-dose injections.
June 1978, The Journal of applied bacteriology,
Copied contents to your clipboard!