The influence of corticosteroids on the fibrinolytic activity in different tissues of the eye was investigated. Rats were treated with corticosteroids, and the fibrinplate method of Todd 1962) was used to estimate the fibrinolytic activity. After 14 days treatment with corticosteroids the fibrinolytic activity decreased. In the control eyes no fibrinolytic activity was left after 6 h of autolysis. The eyes treated with corticosteroids, however, still had fibrinolytic activity.