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Our previous studies have indicated that the synthetic elastase inhibitor N-acetyl-L-alanyl-L-alanyl-L-prolyl-L-alanyl chloromethylketone (AAPACK) administered intraperitoneally in divided doses totaling 19 mg, prior to and after a single intratracheal injection of elastase, substantially inhibited the development of experimental emphysema. The present studies evaluated the effects of 1.1, 4.1 and 8.0 mg AAPACK administered in divided doses 10 min prior to and 10, 30, and 50 min after a single intratracheal dose of elastase. The development of emphysema was essentially eliminated by 4.1 and 8.0 mg of AAPACK and markedly diminished with 1.1 mg AAPACK. The AAPACK was excreted rapidly in the urine at 30 to 60 min after its administration. Elastase inhibitory capacity (EIC) in urine was elevated to 14 times that in serum at the corresponding collection times. The plasma elastase inhibitory capacity was only slightly increased after administration of AAPACK and was not a sensitive indicator of elastase inhibition in the plasma.
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
April 1982,
The American review of respiratory disease,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
May 1989,
The European respiratory journal,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
October 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
January 1980,
Bulletin europeen de physiopathologie respiratoire,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
September 1975,
The Journal of pathology,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
December 1979,
The American review of respiratory disease,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
March 2002,
The European respiratory journal,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
March 1983,
The American review of respiratory disease,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
September 1983,
The American review of respiratory disease,
M P Ip, and
J Kleinerman, and
V Ranga, and
J Sorensen, and
J C Powers
April 1983,
The American review of respiratory disease,
