Biomaterial Database

Pharmacological studies on experimental nephritic rats (2). Antinephritic effect of various drugs on Masugi's nephritis. 1978

Y Suzuki, and M Ito, and T Nagamatsu

Masugi's nephritis was induced in rats by a single i.v. injection of antikidney serum from rabbits immunized with the homogenate of rat whole kidneys. The antinephritic effect of drugs was evaluated through determination of biochemical parameters such as contents of protein and enzymes excreted into the urine and serum cholesterol content by the preadministration and intermittent administration tests. In the preadministration test, of test drugs, betamethasone (0.2 mg/kg +/- 3 p.o.) and azathioprine (25 mg/kg +/- 3 p.o.) showed an antinephritic effect. Betamethasone in particular resulted in normalization of urine and serum parameters. In the intermittent test, all drugs tested were effective. Significant recovery effects were observed with betamethasone (0.1 mg/kg +/- 6 p.o.),, prednisolone (5 mg/kg +/- 6 p.o.), azathioprine (30 mg/kg +/- 6 p.o.), tranexamic acid (200 mg/kg +/- 6 i.p.) and cetraxate (100 mg/kg 6 i.p.) on urinary protein excretion and with all test drugs including indomethacin (5 mg/kg +/- 6 p.o.) and cyclophosphamide (2.5 mg/kg +/- 6 p.o.) on urinary exzyme excretions. Serum cholesterol levels reverted to normal levels after administration of betamethasone. Using this nephritic model, the antinephritic effect of drugs could be tentatively evaluated.

UI	MeSH Term	Description	Entries
D007166	Immunosuppressive Agents	Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.	Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007770	L-Lactate Dehydrogenase	A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.	Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008297	Male		Males
D009393	Nephritis	Inflammation of any part of the KIDNEY.	Nephritides
D011507	Proteinuria	The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	Proteinurias
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000469	Alkaline Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia