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Pseudomembranous colitis (PMC) is an infrequent but serious complication of oral and intravenous antibiotic therapy. Twelve patients with antibiotic-associated PMC, documented by sigmoidoscopy and rectal biopsy, were treated with cholestyramine resin. The mean time from the institution of therapy to cessation of diarrhea was 2.1 days. The response interval bore no relationship to the time symptoms were present prior to therapy. Complete resolution of sigmoidoscopic and histologic evidence of PMC usually accompanied or followed cessation of diarrhea. Obstipation was reported in 5 of 12 patients as a side effect of cholestyramine treatment. Therapy should be continued for up to five days after cessation of diarrhea to prevent recurrence of active PMC. Cholestyramine resin is shown to be an effective treatment for antibiotic-associated PMC.
E W Kreutzer, and
F D Milligan
September 1977,
The New Zealand medical journal,
E W Kreutzer, and
F D Milligan
February 1976,
The Journal of pediatrics,
E W Kreutzer, and
F D Milligan
January 1984,
Reviews of infectious diseases,
E W Kreutzer, and
F D Milligan
July 1981,
American journal of hospital pharmacy,
E W Kreutzer, and
F D Milligan
April 1982,
The American journal of gastroenterology,
E W Kreutzer, and
F D Milligan
May 1985,
American family physician,
E W Kreutzer, and
F D Milligan
December 1981,
Hospital practice (Office ed.),
E W Kreutzer, and
F D Milligan
January 1977,
Canadian Medical Association journal,
E W Kreutzer, and
F D Milligan
May 1990,
American journal of diseases of children (1960),
E W Kreutzer, and
F D Milligan
September 1976,
CRC critical reviews in clinical radiology and nuclear medicine,
