-transparent.png){kind=logo}
Lipid metabolism was studied in experimental uremia. Uremic (U) rats were compared with sham-operated, pair-fed (PF) controls and with ad-lib-fed (AL) controls. In U animals, fasting glucose concentrations were normal, immunoreactive serum insulin (IRI) levels were decreased, and immunoreactive glucagon levels were increased. A significant increase in the serum concentration of all lipid classes was observed: triglycerides were elevated 10-fold above the values in PF and AL controls; phospholipids, twofold; total cholesterol, threefold; and free cholesterol, sixfold. Cholesterol concentration was increased in beta- and pre-beta-lipoproteins and even more so in alpha- and pre-alpha-lipoproteins. There was an increase in the ratio of free cholesterol/total cholesterol. The fatty acid composition of serum lipoproteins was unchanged. Concomitantly, in liver tissue, there was no change in lipid content (triglyceride, cholesterol) and fatty acid composition. These findings argue against glucose- or insulin-mediated changes in hepatic de novo fatty acid synthesis, chain elongation, or poly-desaturation. In U animals, the HMG-CoA-reductase activity of liver microsomes was slightly, but not significantly, reduced as was tritiated water incorporation into cholesterol in isolated perfused liver preparations. In adipose tissue, there was a decrease in triglyceride content. The results provide evidence against insulin-mediated hepatic overproduction as a major cause of hyperlipoproteinemia in this model of experimental renal insufficiency and point to peripheral under-utilization of lipoproteins.
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
January 1980,
Nephron,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
April 1962,
Laboratory investigation; a journal of technical methods and pathology,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
January 1965,
Therapie,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
February 1987,
Experimental and molecular pathology,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
January 1977,
Nephron,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
June 1991,
Annales de pediatrie,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
January 1999,
Srpski arhiv za celokupno lekarstvo,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
October 2003,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
January 1972,
Acta medica Scandinavica,
C C Heuck, and
M Liersch, and
E Ritz, and
K Stegmeier, and
A Wirth, and
O Mehls
December 2001,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
