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Plasma kallikrein, antithrombin III and antiplasmin were determined with chromogenic methods in 29 patients pre-, per- and post-operatively in a controlled, randomized study. 16 patients received calcium heparin, 5000 IU s. c. every 8 hr for 7 days, the first administration given 2 hr before surgical procedure. 13 control patients received saline. A significant reduction of kallikrein and antiplasmin in per- and post-operative periods was observed in the control patients compared with the heparin-treated patients, while there was a significant reduction of anti-thrombin III in the control patients compared with the treated patients only in the per-operative period. The results obtained suggest that activation of the coagulation and fibrinolysis system occurs in patients undergoing thoracic surgery, and that it is inhibited significantly by calcium heparin prophylaxis.
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G Cristoforetti, and
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F Radaelli
July 1983,
Minerva medica,
E M Pogliani, and
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M Colombi, and
G Cristoforetti, and
G Marchetti, and
G Vercesi, and
F Radaelli
January 1980,
Scandinavian journal of haematology. Supplementum,
E M Pogliani, and
A Vigo, and
E Cofrancesco, and
M Colombi, and
G Cristoforetti, and
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G Vercesi, and
F Radaelli
January 1981,
Haemostasis,
E M Pogliani, and
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M Colombi, and
G Cristoforetti, and
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G Vercesi, and
F Radaelli
January 1980,
Acta chirurgica Scandinavica,
E M Pogliani, and
A Vigo, and
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M Colombi, and
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F Radaelli
March 1985,
Minerva medica,
E M Pogliani, and
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May 1973,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
E M Pogliani, and
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F Radaelli
June 1971,
Gruzlica i choroby pluc; tuberculosis et pneumonologia,
E M Pogliani, and
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G Vercesi, and
F Radaelli
January 1977,
Scandinavian journal of thoracic and cardiovascular surgery,
E M Pogliani, and
A Vigo, and
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M Colombi, and
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F Radaelli
June 1984,
Deutsche medizinische Wochenschrift (1946),
E M Pogliani, and
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G Cristoforetti, and
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F Radaelli
December 1972,
Masui. The Japanese journal of anesthesiology,
