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Metergoline (4 mg) and methysergide (3 mg), two serotonin antagonists known to inhibit prolactin secretion in normal subjects, and the dopaminergic agonist, bromocriptine (2.5 mg) were orally administered in hyperprolactinemic patients. Mean serum prolactin concentration was significantly decreased between 120 and 240 min following the ingestion of all three drugs in comparison with a placebo; a consistent reduction to below 50% of basal values occurred in 10 of 14 patients after metergoline, in 5 of 10 after methysergide, and in 11 of 14 after bromocriptine administration. These data indicate that serotonin antagonists may acutely lower serum prolactin levels in hyperprolactinemic patients similarly to bromocriptine, though their mechanism of action is most likely different.
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
January 1980,
Annales d'endocrinologie,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
December 1982,
Life sciences,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
September 1989,
The Journal of clinical endocrinology and metabolism,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
December 1991,
Brain research,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
January 1979,
Hormone research,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
January 1983,
Journal of neural transmission,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
January 1980,
Neuroendocrinology,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
April 1978,
The Journal of clinical endocrinology and metabolism,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
September 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C Ferrari, and
R Caldara, and
P Rampini, and
P Telloli, and
M Romussi, and
A Bertazzoni, and
G Polloni, and
A Mattei, and
P G Crosignani
May 2000,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
