-transparent.png){kind=logo}
We have identified 12 individuals who are heterozygous for a chromosome with three alpha-globin genes. We determined the presence of the third alpha-globin locus by restriction endonuclease digestion and hybridization with alpha-globin cDNA probes. The three alpha-globin loci resided in an elongated fragment on digestion with EcoRI, BamHI, and Xba I, and the third locus was present in an additional 3.7-kilobase fragment on digestion with Hpa I, Sac I, and Bgl II. The locations of the restriction sites are compatible with a nonhomologous crossover mechanism producing the triple alpha loci. The frequency of the triple alpha loci was 0.0036 in American blacks and less than 0.004 in Sardinians, but was higher in Greek Crypriots (0.05). Individuals with five alpha-globin genes (alpha alpha/alpha alpha alpha) apparently showed no clinical or hematologic abnormalities.
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
August 1981,
Nucleic acids research,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
June 1985,
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
November 1983,
Blood,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
January 1985,
Human genetics,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
October 1991,
Klinische Wochenschrift,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
September 1981,
British journal of haematology,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
January 1991,
British journal of haematology,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
March 2008,
Genetics,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
December 1991,
American journal of hematology,
M Goossens, and
A M Dozy, and
S H Embury, and
Z Zachariades, and
M G Hadjiminas, and
G Stamatoyannopoulos, and
Y W Kan
August 2000,
British journal of haematology,
