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Lymphoreticular malignancies occur frequently in association with ataxia-telangiectasia (A-T). This paper presents one new case and reviews all 19 known cases of A-T and acute lymphoblastic leukemia (ALL). The leukemia is associated with poor prognostic factors: male sex, older age, high white blood cell count, and T or B-cells. There have been no long-term survivors; recently, prolonged remissions have been attained. These patients appear to be at special risk for infections secondary to the immunodeficient state associated with A-T and ALL therapy. A heightened sensitivity to the neurotoxic effects of vinca alkaloids and central nervous system irradiation seems to be present.
S R Toledano, and
B J Lange
February 1972,
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S R Toledano, and
B J Lange
February 1969,
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S R Toledano, and
B J Lange
February 1993,
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S R Toledano, and
B J Lange
December 1981,
Tumori,
S R Toledano, and
B J Lange
June 2008,
Pediatric hematology and oncology,
S R Toledano, and
B J Lange
January 1972,
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S R Toledano, and
B J Lange
June 1983,
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S R Toledano, and
B J Lange
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S R Toledano, and
B J Lange
September 2013,
Pediatric hematology and oncology,
S R Toledano, and
B J Lange
June 2013,
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis,
