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In a 3-yr period, the Philadelphia chromosome (Ph1) was found in 4 of 43 children with acute lymphoblastic leukemia (ALL) in whom chromosomes were studied at diagnosis. The clinical, morphological, cytochemical, and immunologic findings in the Ph1-positive (PH1+) CASES WERE CONsistent with typical childhood ALL, indicating that identification of cases requires chromosome studies. A review of all reported cases of Ph1 + childhood ALL shows that Ph1 + patients are older and have higher initial platelet and white blood cell counts (WBC) than most children with ALL. However, a life table comparison between the reported cases of Ph1 + ALL in children and randomly selected age-, sex-, and WBC-matched controls with ALL shows the duration of first marrow remission to be significantly shorter (p less than 0.02) for the Ph1 + cases Ph1 + ALL is a distinct subtype of childhood ALL that is not rare and can be identified only by cytogenetic studies. The prognosis is poor. Cytogenetic studies should be done prospectively in a large group of children with ALL to define further the subgroup of patients and to confirm the findings of this retrospective analysis.
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
March 2011,
Korean journal of pediatrics,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
December 2015,
Hematology (Amsterdam, Netherlands),
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
February 1993,
Hematology/oncology clinics of North America,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
October 2009,
Hematology/oncology clinics of North America,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
June 2022,
The New England journal of medicine,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
January 1983,
Klinische Padiatrie,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
June 1980,
Hiroshima journal of medical sciences,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
June 2013,
Current hematologic malignancy reports,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
January 2007,
Nihon rinsho. Japanese journal of clinical medicine,
J R Priest, and
L L Robison, and
R W McKenna, and
L L Lindquist, and
P I Warkentin, and
T W LeBien, and
W G Woods, and
J H Kersey, and
P F Coccia, and
M E Nesbit
December 2009,
Leukemia & lymphoma,
