Biomaterial Database

Reactions of the dental pulp to microbial provocation of calcium hydroxide treated dentin. 1980

G Bergenholtz, and C Reit

The purpose of the present study was to determine whether treatment of dentin with calcium hydroxide reduces pulp irritation caused by microbial products. The experiment was carried out in three young monkeys. Cavities were prepared on the buccal tooth surface deep into dentin of 62 teeth. Calcium hydroxyde mixed with distilled water was placed in one group of cavities. A set of control cavities received treatment with saline soaked filter-paper discs. The calcium hydroxide dressing and the saline discs were separated from the oral cavity for a period of 14 or 60 d by a Teflon disc and a layer of zinc oxide-eugenol cement. At the end of these periods the content of each cavity was removed and substituted by lyophilized material from cultivated plaque bacteria. After 3 d of exposure the monkeys were killed and the teeth subjected to histologic treatment. Assessments made in the light microscope revealed that pulps subjacent to calcium hydroxide-treated dentin in the majority of cases showed no or only slight infiltrates of inflammatory cells. In controls, 13 out of 22 pulps showed severe inflammatory cell infiltrates or total pulp tissue necrosis. It was concluded that treatment of dentin with calcium hydroxide may reduce the possibility for bacterial components to cause pulp tissue damage.

UI	MeSH Term	Description	Entries
D008251	Macaca	A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.	Ape, Barbary,Ape, Black,Ape, Celebes,Barbary Ape,Black Ape,Celebes Ape,Macaque,Apes, Barbary,Apes, Black,Apes, Celebes,Barbary Apes,Black Apes,Celebes Apes,Macacas,Macaques
D011671	Pulpitis	Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.	Inflammation, Endodontic,Endodontic Inflammation,Endodontic Inflammations,Inflammations, Endodontic,Pulpitides
D002126	Calcium Hydroxide	A white powder prepared from lime that has many medical and industrial uses. It is in many dental formulations, especially for root canal filling.	Hydroxide, Calcium
D003736	Dental Cavity Lining	An inner coating, as of varnish or other protective substance, to cover the dental cavity wall. It is usually a resinous film-forming agent dissolved in a volatile solvent, or a suspension of calcium hydroxide in a solution of a synthetic resin. The lining seals the dentinal tubules and protects the pulp before a restoration is inserted. (Jablonski, Illustrated Dictionary of Dentistry, 1982)	Varnish, Cavity,Cavity Liner, Dental,Cavity Lining Varnish,Cavity Lining Varnishes,Cavity Lining, Dental,Cavity Linings, Dental,Cavity Varnishes,Dental Cavity Liner,Dental Cavity Liners,Dental Cavity Linings,Liners, Dental Cavity,Lining, Dental Cavity,Linings, Dental Cavity,Cavity Liners, Dental,Cavity Varnish,Liner, Dental Cavity,Varnish, Cavity Lining,Varnishes, Cavity,Varnishes, Cavity Lining
D003782	Dental Pulp	A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)	Dental Pulps,Pulp, Dental,Pulps, Dental
D003790	Dental Pulp Necrosis	Death of pulp tissue with or without bacterial invasion. When the necrosis is due to ischemia with superimposed bacterial infection, it is referred to as pulp gangrene. When the necrosis is non-bacterial in origin, it is called pulp mummification.	Dental Pulp Autolysis,Dental Pulp Gangrene,Necrosis, Dental Pulp,Pulp Gangrene,Pulp Mummification,Pulp Necrosis,Autolysis, Dental Pulp,Gangrene, Dental Pulp,Necroses, Pulp,Pulp Autolysis, Dental,Pulp Gangrene, Dental,Pulp Necroses,Pulp Necrosis, Dental,Autolyses, Dental Pulp,Dental Pulp Autolyses,Dental Pulp Necroses,Gangrene, Pulp,Gangrenes, Pulp,Mummification, Pulp,Mummifications, Pulp,Necroses, Dental Pulp,Necrosis, Pulp,Pulp Autolyses, Dental,Pulp Gangrenes,Pulp Mummifications,Pulp Necroses, Dental
D003804	Dentin	The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)	Dentine,Dentines,Dentins
D003809	Dentin, Secondary	Dentin formed by normal pulp after completion of root end formation.	Secondary Dentin,Dentins, Secondary,Secondary Dentins
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001424	Bacterial Infections	Infections by bacteria, general or unspecified.	Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases