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Sudden cerebrovascular insults occurred during or immediately following remission induction therapy in 4 children with acute lymphoblastic leukemia. In 3, cerebral infarction was due to thrombosis. In the fourth, an intracerebral hematoma developed representing either frank hemorrhaging or a hemorrhagic infarction. None of the patients had central nervous system leukemia or extreme leukocytosis at the time of diagnosis. Symptoms were obtundation, hemiparesis, seizures, and headache. The induction chemotherapy included L-asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI. These hemostatic abnormalities may explain the thromboses and bleeding observed in these children.
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
January 1993,
Current opinion in oncology,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
September 1983,
The Journal of pediatrics,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
February 2000,
Neurology,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
August 2017,
Expert opinion on pharmacotherapy,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
November 2005,
Personalized medicine,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
January 1980,
American journal of diseases of children (1960),
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
August 2002,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
January 1992,
Medical and pediatric oncology,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
September 2008,
Nature clinical practice. Oncology,
J R Priest, and
N K Ramsay, and
R E Latchaw, and
L A Lockman, and
D K Hasegawa, and
T D Coates, and
P F Coccia, and
J R Edson, and
M E Nesbit, and
W Krivit
September 2000,
Cancer research,
