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Inhalation exposure experiments with the direct-acting alkylating agent epichlorohydrin (ECH) were done on noninbred male Sprague-Dawley rats. Single 6-hour exposure to ECH and follow-up for 14 days showed the median lethal concentration to be about 360 ppm. Further inhalation experiments were done with 6-hour exposure 5 days/week. A short-term 30-exposure regimen with 100 ppm ECH produced malignant squamous cell carcinomas of the nasal cavity in 15 of 140 rats and respiratory tract papillomas in 3 rats. Among 100 rats, lifetime exposure to 30 ppm yielded 1 malignant squamous carcinoma of the nasal cavity plus 1 nasal papilloma. No nasal or respiratory tract tumors were produced by lifetime exposure of 100 rats to 10 ppm. As controls, 100 air-treated and 50 untreated rats were used. A dose-rate effect was observed for ECH inasmuch as 30-day exposure to 100 ppm (3,000 ppm-days) produced 15 cancers in comparison to the 1 cancer from the lifetime exposure to 30 ppm (8,700 ppm-days) and no cancers from lifetime exposure to 10 ppm (2,500 ppm-days).
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
June 1990,
Environmental health perspectives,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
January 1996,
Drug and chemical toxicology,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
December 1976,
Journal of the National Cancer Institute,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
September 1978,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
May 1978,
Cancer letters,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
July 2010,
Drug and chemical toxicology,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
June 1977,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
January 2012,
The Journal of toxicological sciences,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
January 1988,
Annals of the New York Academy of Sciences,
S Laskin, and
A R Sellakumar, and
M Kuschner, and
N Nelson, and
S La Mendola, and
G M Rusch, and
G V Katz, and
N C Dulak, and
R E Albert
January 1988,
Annals of the New York Academy of Sciences,
