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We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/monocyte committed progenitor cells (CFU-c) by an agar method. Circulating erythroid burst-forming units (BFU-e) in CGL were increased above normal by a factor of about 180; CFU-c were increased by a factor of about 9000. Both BFU-e and CFU-c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU-c and BFU-e numbers. Circulating BFU-e and erythroid colony-forming cells (CFU-e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the 'clonal expansion' that characterizes CGL, but apparently to a lesser extent than are granulocyte/moonocyte progenitor cells.
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
January 1979,
Haematology and blood transfusion,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
October 1968,
Lancet (London, England),
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
May 1977,
British medical journal,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
January 1982,
Acta haematologica,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
November 1974,
British medical journal,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
May 1990,
The Journal of the Association of Physicians of India,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
January 1970,
Beitrage zur Pathologie,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
May 1964,
Lancet (London, England),
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
July 1974,
The Medical journal of Australia,
J M Goldman, and
F Shiota, and
K H Th'ng, and
K H Orchard
July 1977,
British medical journal,
