Biomaterial Database

Histopathologic differences between liver tumors in untreated (C57BL/6 X C3H)F1 (B6C3F1) mice and Nitrofen-fed mice. 1980

K L Hoover, and J M Ward, and S F Stinson

A comparison was made of the histologic characteristics of naturally occurring and Nitrofen-induced liver tumors in (C57BL/6 X C3H)F1 (B6C3F1) mice. Whereas induced tumors generally consisted of solid sheets or nodules of frequently enlarged eosinophilic hepatocytes containing enlarged and/or hyperchromatic nuclei, the spontaneous neoplasms consisted predominantly of small basophilic cells containing oval or round nuclei and frequently arranged in trabeculae 1--2 cells wide. Within the livers of Nitrofen-treated animals, foci of hepatocytes resembling those within the tumor masses were also observed in the nonneoplastic areas. Metastases were not present in the lungs of any controls, whereas small emboli or large masses of neoplastic hepatocytes were present in incidences up to 29% in treated mice with tumors. This bioassay provides evidence that, in some cases, liver tumors in treated mice are morphologically different from those in controls and suggests that Nitrofen induces unique liver tumors rather than acts as a promoter of spontaneous neoplasms.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008114	Liver Neoplasms, Experimental	Experimentally induced tumors of the LIVER.	Hepatoma, Experimental,Hepatoma, Morris,Hepatoma, Novikoff,Experimental Hepatoma,Experimental Hepatomas,Experimental Liver Neoplasms,Hepatomas, Experimental,Neoplasms, Experimental Liver,Experimental Liver Neoplasm,Liver Neoplasm, Experimental,Morris Hepatoma,Novikoff Hepatoma
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D010647	Phenyl Ethers	Ethers that are linked to a benzene ring structure.	Diphenyl Oxide,Diphenyl Oxides,Diphenyl Ethers,Ethers, Diphenyl,Ethers, Phenyl,Oxide, Diphenyl,Oxides, Diphenyl
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus