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The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) is known to be activated to a potent mutagen in the Salmonella test system and to induce kidney tumors in long-term feeding studies in mice and rats. Administration of Tris-BP to rats leads to extensive tubular necrosis at doses of 250 mg/kg i.p. and higher. The histological lesion is present in most animals 24 h after administration. There is a close correlation between the increase in kidney weights, the degree of kidney damage and the increase in plasma urea levels. A continuous increase in kidney weights with respect to time is seen, 7 days after a dose of 250 mg/kg i.p. the kidney/body weight ratio is 192% of controls. The kidney damage is not altered by previous phenobarbital-treatment, whereas cobaltous chloride, an inhibitor of cytochrome P-450, slightly reduces the kidney damage.
E Dybing, and
E Søderlund
January 1982,
Toxicology and applied pharmacology,
E Dybing, and
E Søderlund
January 1977,
Science (New York, N.Y.),
E Dybing, and
E Søderlund
July 1978,
Mutation research,
E Dybing, and
E Søderlund
March 1983,
Toxicology and applied pharmacology,
E Dybing, and
E Søderlund
December 1977,
Contact dermatitis,
E Dybing, and
E Søderlund
December 1977,
Journal of toxicology and environmental health,
E Dybing, and
E Søderlund
January 1999,
IARC monographs on the evaluation of carcinogenic risks to humans,
E Dybing, and
E Søderlund
January 2011,
Report on carcinogens : carcinogen profiles,
E Dybing, and
E Søderlund
January 2004,
Report on carcinogens : carcinogen profiles,
E Dybing, and
E Søderlund
January 2002,
Report on carcinogens : carcinogen profiles,
