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Short term biocompatibility of biomaterials including various dental materials has been elucidated so far. When considering the practical cases of utilization of the biomaterials, it is known that they stay for quite a long period in situ once after brought into the living system. It seems, therefore, essential that long term biocompatibility of the materials should be clarified in order to provide better knowledge on various aspects of biocompatibility. The present paper deals with long term biocompatibility in vitro of common dental materials, dental amalgams.
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