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The pathogenesis of the anemia which occurs in rats bearing the Shay chloroleukemia (SCL) was investigated. Severe anemia, shown not to result from hemodilution, developed in the terminal stage of the disease. The rapid progression of the anemia suggested that reduced erythropoiesis was of no more than minor importance in the development of this anomaly. No evidence for a major hemolytic event was observed. Data are presented which suggest that hemostatic defects may be primarily responsible for the anemia of SCL. Because of many similarities with the pathogenesis of human myelogenous leukemia, SCL is proposed as a useful model for further studies on interreactions between the leukemic environment and the erythrocyte population.
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
May 1977,
Journal of the National Cancer Institute,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
September 1967,
Cancer research,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
March 1970,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
January 1957,
Annales medicinae experimentalis et biologiae Fenniae,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
August 1970,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
March 1951,
Casopis lekaru ceskych,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
March 1969,
Japanese journal of pharmacology,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
May 1954,
Archives des maladies de l'appareil digestif et des maladies de la nutrition,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
December 1951,
Minerva pediatrica,
M J Derelanko, and
J LoBue, and
J A Khouri, and
R C Meagher, and
A J Burdowski, and
S Piliero, and
A S Gordon
October 1957,
Annals of the New York Academy of Sciences,
