BIOMAT Database Logo BIOMAT Database Logo

The significance of splenomegaly in 101 adults with acute lymphoblastic leukemia (ALL) at presentation and during remission. 1981

A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson

One-hundred-one adult patients with ALL were analyzed to determine the prognostic implications of splenomegaly occurring at any time during the course of their illness. The clinical status of the spleen at presentation was not found to be of major prognostic significance. Complete response rates, remission durations, and survivals did not differ between patients with and without splenomegaly at presentation. An enlarged spleen accompanied relapse in four patients. In six additional patients, splenomegaly was present during complete remission, and splenectomies performed in five of these patients revealed no evidence of leukemia to account for the splenomegaly. Splenectomy does not appear to be detrimental, as all five patients are currently in complete remission from 20 to 63 mo after splenectomy. Evidence implicating the spleen as a source of an antibody directed against autologous leukemia cells in one patient is reviewed.

UI MeSH Term Description Entries
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D013156 Splenectomy Surgical procedure involving either partial or entire removal of the spleen. Splenectomies

Related Publications

A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Isolated splenomegaly during remission in childhood acute lymphoblastic leukemia.
January 1985, The Turkish journal of pediatrics,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Significance of splenomegaly in childhood acute lymphoblastic leukaemia in remission.
March 1980, Lancet (London, England),
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Remission Rate of Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA).
February 2018, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Neuroblastoma during acute lymphoblastic leukemia in remission.
October 1988, Cancer,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Lymphocyte functions of child patients with ALL (acute lymphoblastic leukemia) in remission.
March 1984, Japanese journal of clinical oncology,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Childhood acute lymphoblastic leukemia with hyperleukocytosis at presentation.
March 2014, Blood research,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
[Three cases of acute leukemia with splenomegaly during hematological remissions. Effect of splenectomy and significance of splenomegaly as a criterion for complete remission in acute leukemia (author's transl)].
April 1978, [Rinsho ketsueki] The Japanese journal of clinical hematology,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Pre-B Acute Lymphoblastic Leukemia During a Complete Remission in T-Acute Lymphoblastic Leukemia.
January 1991, Leukemia & lymphoma,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Intestinal perforation during remission of acute lymphoblastic leukemia.
March 1979, The Journal of pediatrics,
A Friedman, and P Schauer, and R Mertelsmann, and C Cirrincione, and H Thaler, and P Dufour, and S B Ellis, and H Teitelbaum, and S Kempin, and T S Gee, and Z Arlin, and B Clarkson
Marrow culture studies in adult acute leukemia at presentation and during remission.
June 1977, Blood,
Copied contents to your clipboard!