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The syndrome of hyperuricosuric calcium oxalate nephrolithiasis, consisting of calcium oxalate stones, hyperuricosuria and the absence of known causes of calcium stones, follows a course of particularly severe stone disease. This course can be dramatically altered by the reduction in new stone formation by the chronic administration of allopurinol. The mechanisms proposed in linking hyperuricosuria to calcium oxalate stones are both dependent upon the presence of oversaturation of the urine with one or both species of uric acid. Allopurinol reduces the saturation of the urine with respect to sodium hydrogen urate and reduces urine concentration of undissociated uric acid, thus directly altering the pathogenetic mechanisms proposed for this disorder.
M J Favus, and
F L Coe
November 1984,
The Journal of urology,
M J Favus, and
F L Coe
January 1981,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
M J Favus, and
F L Coe
January 1987,
Mineral and electrolyte metabolism,
M J Favus, and
F L Coe
January 1988,
European urology,
M J Favus, and
F L Coe
November 1992,
British journal of urology,
M J Favus, and
F L Coe
February 1973,
Lancet (London, England),
M J Favus, and
F L Coe
December 1978,
British journal of urology,
M J Favus, and
F L Coe
January 2003,
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation,
M J Favus, and
F L Coe
July 1986,
The Journal of urology,
M J Favus, and
F L Coe
October 1984,
Hinyokika kiyo. Acta urologica Japonica,
