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The effect of aclacinomycin A on the survival of cultured mouse L cells was studied. The drug showed a characteristic dose-survival response, i.e., an initial exponential responses followed by a sigmoidal inactivation characterized by a broad shoulder. With prolongation of the exposure time, the exponential response seen at a low concentration was remarkably intensified with a progressive decrease of the shoulder width. Two-dose fractional survival studies revealed that at least a portion of the shoulder region relation to an accumulation of sublethal damage which can be repaired during 12 hr after the first dose. The implication of these results for therapeutic scheduling is discussed.
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
October 1972,
Gan,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
January 1988,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
June 1970,
The Journal of antibiotics,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
June 1972,
Gan,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
August 1967,
Acta pathologica japonica,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
July 1976,
Mutation research,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
July 1976,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
June 1974,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
August 1986,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
M Tanabe, and
T Miyamoto, and
Y Nakajima, and
T Terasima
November 1973,
Cancer research,
