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The effects of atropine and pirenzepine on sham-feeding stimulated gastric secretion and serum gastrin and pancreatic polypeptide levels have been studied in 12 patients with duodenal ulcer. Both atropine and pirenzepine caused a dose-dependent decrease in acid and pepsin secretion induced by sham-feeding. Serum gastrin response to sham-feeding was negative and it was enhanced by atropine but suppressed by pirenzepine. Plasma pancreatic polypeptide level, which was markedly increased by sham-feeding, was abolished both by atropine and pirenzepine. This study shows that pirenzepine is a more selective inhibitor of gastric secretory and serum hormonal responses to sham-feeding than atropine and that it may be a useful tool for studying the cholinergic innervation of the oxyntic glands and the G-cells in man.
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
December 1981,
Gut,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
June 1986,
Hepato-gastroenterology,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
November 1969,
Acta physiologica Scandinavica,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
November 1986,
Scandinavian journal of gastroenterology,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
August 1990,
Alimentary pharmacology & therapeutics,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
January 1974,
Scandinavian journal of gastroenterology,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
January 1978,
Scandinavian journal of gastroenterology,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
January 1979,
Scandinavian journal of gastroenterology,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
April 1989,
Annals of surgery,
S J Konturek, and
W Obtulowicz, and
N Kwiecień, and
M Dobrzańska, and
J Swierczek, and
B Kopp, and
J Olesky
January 1985,
Digestion,
