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The capacity of blood mononuclear cells to produce procoagulant activity upon stimulation with bacterial endotoxin in vitro was studied in 21 untreated patients with chronic myeloid leukaemia (CML). Procoagulant activity developed by patients' cells after prolonged incubation with endotoxin was significantly lower than that produced by cells from a matched control group (P less than 0.001). Reduced activity was seen in all patients when each of them was compared to a matched control studied simultaneously. It was below 50% of the control in 19 patients, and in eight of these it was less than 10%. These findings suggest that qualitative abnormalities in mononuclear cell function may exist in CML and might explain why these patients are less prone to thrombotic complications than those with other myeloproliferative diseases.
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
January 1985,
Journal of leukocyte biology,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
August 1983,
Scandinavian journal of haematology,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
April 1987,
Transplantation,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
July 1986,
European journal of cancer & clinical oncology,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
October 1992,
Thrombosis research,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
May 1991,
The Journal of surgical research,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
January 2023,
Frontiers in oncology,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
January 1997,
Respiration; international review of thoracic diseases,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
January 2017,
Acta haematologica,
S Cortellazzo, and
P Viero, and
T Barbui, and
M Colucci, and
N Semeraro
June 2017,
Experimental biology and medicine (Maywood, N.J.),
