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Medullary granulocyte progenitor (CFUc) cultures were grown in vitro from samples taken from 6 patients with toxic granulocytopenia caused by either thiamphenicol cephalothin or amidopyrine and who are now apparently cured. A decreased in the medullary concentration of CFUc has been observed and a calculated estimate shows that there was a decrease in their absolute number. A decrease in the number of CFUc per 10(5) metamyelocytes suggests a possible compensation by mitotic amplification between the stem cell and the differentiated cells. Two successive cultures have shown that the course of such medullary cultures is variable. The existence of medullary anomalies before drug toxicity as well as the practical consequences of the contrast between the apparent cure and the decrease in CFUc are discussed.
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
February 1985,
Experimental hematology,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
January 1978,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
May 1982,
Cell and tissue kinetics,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
August 1981,
Experimental hematology,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
December 1976,
Cancer research,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
January 1978,
International journal of radiation oncology, biology, physics,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
January 1978,
International journal of radiation oncology, biology, physics,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
June 1977,
Cancer research,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
April 1983,
Pediatric research,
C Parmentier, and
G Tchernia, and
E Subtil, and
L Diakhate, and
N Morardet
November 1982,
Experimental hematology,
