-transparent.png){kind=logo}
Elevation of the mean arterial blood pressure to approximately 150 mmHg by infusion of angiotensin II resulted in an approximate 5.7-fold selective increase in blood flow in tumor tissue without increasing blood flow in normal tissue. This finding of no autoregulation of blood flow in tumor tissue was made in an experiment on inbred DONRYU rats with sc transplanted AH109A solid tumors (Yoshida ascites hepatoma). Changes in tissue blood flow were measured by a thermoelectrical method. In another experiment in which DONRYU rats with sc transplanted AH272 solid tumors were used, the chemotherapeutic effect of mitomycin C on main tumors and lymph node metastatic foci was markedly enhanced in rats with angiotensin-induced hypertension, as compared to its effect in rats without angiotensin-induced hypertension. Thus a new approach to cancer chemotherapy has been demonstrated in which the delivery to tumor tissue of systemically administered anticancer drugs can be selectively enhanced.
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
July 1991,
No to shinkei = Brain and nerve,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
April 2001,
Nihon rinsho. Japanese journal of clinical medicine,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
June 1990,
Journal of neuro-oncology,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
September 1996,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
November 1985,
Cancer research,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
January 1981,
Hypertension (Dallas, Tex. : 1979),
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
January 1960,
Acta - Unio Internationalis Contra Cancrum,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
April 1984,
Harefuah,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
March 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Suzuki, and
K Hori, and
I Abe, and
S Saito, and
H Sato
February 1990,
The American journal of physiology,
