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Platelet factor 4 is shown to be a chemotactic protein for human polymorphonuclear leukocytes and monocytes at concentrations found in human serum and reached locally in injured tissue. The maximum chemotactic response to platelet factor 4 nearly equals that achieved with saturating concentrations of the chemotactic activity derived from the fifth component of human complement, C5. Cells desensitized to C5 chemotactic activity retain chemotactic responsiveness to platelet factor 4. Serum contains inhibitory capacity against the chemotactic activity associated with platelet factor 4. Our results suggest that the local release of platelet factor 4 may be an important stimulus attracting inflammatory cells to sites of blood vessel injury.
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
August 1992,
Gut,
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
February 1989,
Experimental cell research,
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
March 1987,
Journal of immunology (Baltimore, Md. : 1950),
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
June 1988,
Biochemical and biophysical research communications,
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
August 1988,
Clinical nephrology,
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
September 1978,
Nature,
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
April 2003,
Shock (Augusta, Ga.),
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
July 2007,
Journal of immunology (Baltimore, Md. : 1950),
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
January 1984,
Science (New York, N.Y.),
T F Deuel, and
R M Senior, and
D Chang, and
G L Griffin, and
R L Heinrikson, and
E T Kaiser
January 1990,
Progress in clinical and biological research,
