-transparent.png){kind=logo}
A monoclonal antibody specific for a common acute lymphoblastic leukemia (ALL) antigen has been generated and characterized. This antibody (J-5) is reactive with leukemic cells from most patients with non-T-cell ALL and some patients with chronic myelocytic leukemia in blast crisis. J-5 antibody is not reactive with leukemic cells from patients with either T-cell ALL, chronic lymphocytic leukemia, acute myeloblastic leukemia, or stable-phase chronic myelocytic leukemia. In addition to diagnostic applications, anti-common ALL antigen monoclonal antibody has been used to study the effect of specific serotherapy in the treatment of ALL. In the first patient with ALL treated with J-5 antibody, a 90% reduction in circulating lymphoblasts occurred within 1 hr of starting antibody infusion. Despite continued serotherapy, however, lymphoblasts persisted in peripheral blood and bone marrow. Analysis of cell surface markers during serotherapy suggested that resistance to antibody-mediated lysis in vivo may have been due to antigenic modulation of leukemic cells in response to J-5 monoclonal antibody.
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
July 1988,
Orvosi hetilap,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
June 2015,
Blood,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
November 1988,
Pediatria polska,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
April 2012,
Hematology (Amsterdam, Netherlands),
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
December 2020,
Best practice & research. Clinical haematology,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
January 1985,
Pharmacology & therapeutics,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
January 1985,
Pathology,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
September 1985,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
January 2015,
Hematology. American Society of Hematology. Education Program,
J Ritz, and
J M Pesando, and
J Notis-McConarty, and
L A Clavell, and
S E Sallan, and
S F Schlossman
January 1984,
La Ricerca in clinica e in laboratorio,
