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Measures of daily urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion and electroencephalographic (EEG) sleep data were examined in 30 patients hospitalized for depression. This sample (mean age = 35 years) comprised 17 females and 13 males, all of whom were drug-free for 2 weeks and met Research Diagnostic Criteria for primary depressive disorder. Data analyses were conducted on the entire group, as well as the male, female, unipolar, and recurrent subgroups. No significant relationships were observed between total MHPG excretion and rapid eye movement (REM) or non-REM sleep variables. In particular, the absence of an interrelatedness of MHPG and REM sleep fails to confirm earlier findings in a smaller patient sample. These results, therefore, raise new questions about the proposed role of central noradrenergic activity in the mediation of REM sleep in depression.
D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
January 1977,
Neuropsychobiology,
D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
July 1980,
Psychiatry research,
D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
October 1973,
Brain research,
D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
September 1972,
The American journal of psychiatry,
D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
April 1979,
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D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
June 1988,
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D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
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D J Kupfer, and
B C Holzer, and
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P A Coble, and
D G Spiker, and
J F Neil
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D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
January 1979,
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D J Kupfer, and
B C Holzer, and
D J Edwards, and
P A Coble, and
D G Spiker, and
J F Neil
March 1972,
Archives of general psychiatry,
