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Eighteen patients, aged 18-84 years, with complicated urinary tract infections admitted to hospital were treated preoperatively with azlocillin (Securopen) for 5 to 10 days. Two patients having chronic pyelonephritis were not operated. Isolates bacteria were Pseudomonas aeruginosa (14), Proteus mirabilis (3), Escherichia coli (2) and Klebsiella spp. (1). Serum concentrations and urine recovery were measured on the fifth day of treatment. The mean serum half-life was 1.85 h and the mean value of the urine recovery 47% of the single dose. On the 5th day of treatment the urine was sterile in 80% of the patients. In 12 patients (60%) the urine was still sterile when controlled 2-6 months after operation and prophylactic postoperative treatment with nitrofurantoin or trimethoprim-sulfamethoxazole.
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