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In three cases of acute myeloid leukaemia marked increases in expression of the nuclear enzyme, terminal deoxynucleotidyl transferase (TdT), were observed during disease relapse. The first case was heterogeneous at diagnosis, consisting of subpopulations of large TdT- myeloblasts and small TDT+ blasts; however, at relapse there was complete replacement by TdT+ lymphoblasts. The other cases at diagnosis were both typical acute myeloid leukaemia, TdT-; at relapse, one showed a mixture of TdT- myeloblasts and TdT+ lymphoblasts, while in the other, TdT was demonstrated on a subpopulation of myeloblasts. No chromosomal abnormalities were found. It is suggested that in the first two cases these phenomena may have been due to leukaemic involvement of a pluripotential stem cell, or that sub-clones with different properties may have coexisted. In the third case at relapse, TdT was expressed aberrantly by malignant myeloid cells.
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
May 1991,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
January 1983,
Leukemia research,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
July 1993,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
June 1988,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
January 2012,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
October 1988,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
August 1993,
Leukemia,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
May 2006,
Reviews on recent clinical trials,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
September 1999,
British journal of haematology,
K F Bradstock, and
G Pizzolo, and
E S Papageorgiou, and
G L Cetto, and
H G Prentice, and
K Ganeshaguru, and
A G Prentice, and
A Smith, and
M Chilosi, and
A Ambrosetti, and
A V Hoffbrand
June 1984,
Lancet (London, England),
