Histologic study of pulp capping in rat molars using calcitonin. 1982

H S Smith, and N N Soni

Calcitonin, a calcium regulating hormone, has been found to affect bone formation and resorption. In this study a calcitonin preparation and a calcium hydroxide preparation for comparison were applied to both exposed and unexposed rat molar pulps. Histologic examinations were conducted after periods of 1 day to 28 days. Calcium hydroxide pulp caps produced varying amounts of secondary dentin and inflammation. Calcitonin applied as an indirect agent had a similar effect. When calcitonin was applied to exposed pulp, a large amount of dense fibrous connective tissue reminiscent of scar tissue was formed. With increased time this connective tissue exhibited signs of progressive, orderly calcification continuing through a large portion of the coronal pulp.

UI MeSH Term Description Entries
D008963 Molar The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821) Molars
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002116 Calcitonin A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults. Thyrocalcitonin,Calcitonin(1-32),Calcitrin,Ciba 47175-BA,Eel Calcitonin,Calcitonin, Eel,Ciba 47175 BA,Ciba 47175BA
D002126 Calcium Hydroxide A white powder prepared from lime that has many medical and industrial uses. It is in many dental formulations, especially for root canal filling. Hydroxide, Calcium
D003782 Dental Pulp A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992) Dental Pulps,Pulp, Dental,Pulps, Dental
D003785 Dental Pulp Capping Application of a protective agent to an exposed pulp (direct capping) or the remaining thin layer of dentin over a nearly exposed pulp (indirect capping) in order to allow the pulp to recover and maintain its normal vitality and function. Pulp Capping,Capping, Dental Pulp,Capping, Pulp,Pulp Capping, Dental,Cappings, Dental Pulp,Cappings, Pulp,Dental Pulp Cappings,Pulp Cappings,Pulp Cappings, Dental
D003809 Dentin, Secondary Dentin formed by normal pulp after completion of root end formation. Secondary Dentin,Dentins, Secondary,Secondary Dentins
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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