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38 children with acute lymphocytic leukaemia (ALL) in haematologic relapse were retreated with vincristine, daunomycin and prednisone (VPD) together with intrathecal methotrexate and prednisone, followed by asparaginase in those patients not in complete remission after 4 weeks. The overall complete remission (CR) rate was 79%; asparaginase was needed to achieve CR in 7 of the 30 responding patients. The median duration of second remission was only 36 weeks, but 6 out of 15 children receiving the COAP-POMP-CART consolidation regimen remain in continuous second remission after 37-260 weeks; 3 of them are currently off all therapy. It is concluded that a prolonged second remission can be achieved in children with ALL in bone marrow relapse by combining intensive chemotherapy with the prevention of meningeal leukaemia.
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
August 1985,
Scandinavian journal of haematology,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
March 1982,
Blut,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
January 1979,
Medical and pediatric oncology,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
September 1975,
Archives of disease in childhood,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
January 1978,
American journal of hematology,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
December 1979,
British journal of cancer,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
September 1983,
Cancer treatment reviews,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
May 2007,
The Australasian journal of dermatology,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
October 1984,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
S Amadori, and
M A Spiriti, and
G Meloni, and
L Pacilli, and
G Papa, and
F Mandelli
May 2009,
Journal of clinical pathology,
