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Temperature distribution in tissues subjected to local hyperthermia by RF induction heating. 1982

J W Hand, and J L Ledda, and T S Evans

We have used a finite difference formulation of the bio-heat transfer equation to predict temperature distributions in and around a non-uniformly perfused volume located in layered tissue. Using available data on blood flow in experimental tumours we have shown that techniques capable of highly localized heating are required to treat small, well perfused tumours effectively. However, the r.f. technique considered here produces acceptable temperature distributions in larger tumours with poorly perfused centres. Skin cooling improves the effective penetration of the hyperthermal treatment and may improve the uniformity of heating. However, the considerable heat flux through superficial tissues associated with chilled water cooling can produce large temperature gradients in such regions.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011846 Radio Waves Electromagnetic waves with frequencies between about 3 kilohertz (very low frequency - VLF) and 300,000 megahertz (extremely high frequency - EHF). They are used in television and radio broadcasting, land and satellite communications systems, radionavigation, radiolocation, and DIATHERMY. The highest frequency radio waves are MICROWAVES. Hertzian Waves,High Frequency Waves,Radiowave,Radiowaves,Short Waves,Very High Frequency Waves,Frequency Wave, High,Frequency Waves, High,High Frequency Wave,Radio Wave,Short Wave,Wave, High Frequency,Wave, Radio,Wave, Short,Waves, Hertzian,Waves, High Frequency,Waves, Radio,Waves, Short
D004735 Energy Transfer The transfer of energy of a given form among different scales of motion. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed). It includes the transfer of kinetic energy and the transfer of chemical energy. The transfer of chemical energy from one molecule to another depends on proximity of molecules so it is often used as in techniques to measure distance such as the use of FORSTER RESONANCE ENERGY TRANSFER. Transfer, Energy
D006358 Hot Temperature Presence of warmth or heat or a temperature notably higher than an accustomed norm. Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions

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