-transparent.png){kind=logo}
A genomic clone encoding H-2Ld, a mouse major transplantation antigen, has been identified and the structure of the H-2Ld gene has been partially determined. We isolated 35 genomic clones from a BALB/c (H-2d) genomic library by hybridization to mouse or human probes. One of these clones encodes H-2Ld as determined by two criteria. First, the gene encodes a protein that is identical at the 76 known amino acid positions for H-2Ld. Second, when introduced into L cells by DNA-mediated gene transfer, a new H-2 antigen is expressed that is recognized by anti-H-2Ld monoclonal antibodies. The sequence of the H-2Ld protein predicted by the DNA sequences shows more than 80% homology to known H-2 antigens. H-2L-like sequences are found in mutant H-2Kb molecules, suggesting that gene conversion or reciprocal recombination may play a role in the development of H-2 polymorphism.
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
December 1985,
The EMBO journal,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
February 1985,
The Journal of experimental medicine,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
June 1987,
Cancer research,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
December 1980,
Journal of immunology (Baltimore, Md. : 1950),
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
May 1981,
Proceedings of the National Academy of Sciences of the United States of America,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
February 1988,
Journal of immunology (Baltimore, Md. : 1950),
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
November 2013,
The Journal of biological chemistry,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
May 1993,
Biology of reproduction,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
January 1994,
Autoimmunity,
G A Evans, and
D H Margulies, and
R D Camerini-Otero, and
K Ozato, and
J G Seidman
February 1996,
European journal of biochemistry,
