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A field study was performed on 118 members of army personnel with the intranasally-applied live influenza vaccine, RIT 4050. 91 subjects were revaccinated 7 days thereafter. The immune response was best in subjects with a low prevaccination titre and was better in subjects vaccinated twice than only once. An immune response was also detected in the nasal secretion measuring the secretory IgA antibodies. Live influenza vaccine can be regarded as a suitable alternative to other influenza vaccines, with the qualification that it lacks an influenza B component.
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