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The influence of phenobarbitone givenin ten repeated doses simultaneously with small doses of CCl4 on serum enzymes was investigated in albino rats. The same experiment was repeated to investigate the influence of propionyl-promazine (phenothiazine derivative). The results proved that SGPT is a more specific and sensitive index than SGOT of hepato-cellular injury. The activity ratio between serum GOT and GPT in the normal control group was 2.44. The activity of SGPT increased nearly 6.1 fold after CCl4 administration and thus the activity ratio between GOT and GPT is sharply reduced to 0.56. The activity of serum GPT when CCl4 and phenobarbitone were administered together showed value of about 1/2 of the value when CCl4 was administered alone, while it remained high when CCl4 administration was combined with propionyl-promazine. Serum GOT and alkaline phosphatase increased significantly in all the groups. Regarding the pathological examination of the liver it was found that marked fatty necrosis could be demonstrated when high values of SGPT was found, which is not the case with serum GOT. It is concluded that in the present experimental conditions phenobarbitone protected the liver from the hepatotoxic effect of CCl4, while propionyl-promazine did not.
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
March 1978,
Zeitschrift fur Ernahrungswissenschaft,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
January 1966,
Federation proceedings. Translation supplement; selected translations from medical-related science,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
March 1971,
Toxicology and applied pharmacology,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
January 1965,
Voprosy meditsinskoi khimii,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
January 1958,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
December 1982,
Biochemical pharmacology,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
January 1990,
Enzyme,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
June 1960,
A.M.A. archives of industrial health,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
August 1960,
Archives of environmental health,
E A el-Dessoukey, and
H M Tahani, and
R Awadallah, and
H A Zinat, and
N A Kotb
January 1969,
Acta pharmacologica et toxicologica,
