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The analysis of the effects of pirenzepine (0.2 mg/kg body weight) on S35 uptake of rat colonic mucus was studied by gel permeation chromatography. As it is well known, with this method two fractions - peak A and peak B - are clearly distinguished. In the included volume (peak B) pirenzepine decreases significantly the S35 uptake in the stimulated right colon. In the left one, the above effect was observed under both conditions: basal and stimulated. In the void volume (peak A), pirenzepine under basal conditions inversely shows an increase of the S35 uptake, whereas under stimulated conditions it reveals anticipated kinetic increase. Statistically, this data is less significant than that of peak B. All the findings demonstrated that muscarinic receptors of high sensitivity are present in rat colon.
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
March 1978,
Carbohydrate research,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
January 1991,
Life sciences,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
January 1986,
Pancreas,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
January 1979,
Scandinavian journal of gastroenterology. Supplement,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
September 1978,
The American journal of gastroenterology,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
June 2001,
Digestive diseases and sciences,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
January 1980,
Investigative & cell pathology,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
July 1979,
British journal of pharmacology,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
February 1975,
The American journal of digestive diseases,
L Bustos-Fernaández, and
J A Kofoed, and
E Gonzalez, and
M I Ledesma-Paolo
November 1985,
European journal of pharmacology,
