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In a prospective study of 26 patients with macroadenoma of the pituitary (14 secretory and 12 non-secretory), basal and stimulated pituitary hormone levels were used to detect hypothalamic dysfunction and to examine pituitary hormone secretion before and after hypophysectomy. Suprasellar tumour extention with hypothalamic compression occurred in 18 patients but was not consistently associated with hormonal tests indicative of hypothalamic dysfunction. In patients with secretory tumours, secretory activity was adequately assessed by basal hormone levels alone, which showed that surgery reduced hormone levels by a mean 85% in acromegaly and by a mean 55% in prolactinomas. Preoperatively, pituitary reserve of hormones not being hypersecreted was often normal, despite large tumour size and hypothalamic compression. Even after apparently complete pituitary removal at surgery, normal responses to stimulatory tests could sometimes be detected. Conventional dynamic tests are only of limited value in the assessment of hypothalamo-pituitary dysfunction in patients with large pituitary tumours and should not be used indiscriminately in such individuals requiring surgery.
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
November 1968,
Lancet (London, England),
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
June 1973,
Acta endocrinologica,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
January 1991,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
August 1988,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
April 1982,
Fertility and sterility,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
February 1966,
Australasian annals of medicine,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
January 1972,
Annales d'endocrinologie,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
January 2003,
Journal of endocrinological investigation,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
May 1982,
Nihon Sanka Fujinka Gakkai zasshi,
J D Best, and
F P Alford, and
D J Chisholm, and
P Mowat, and
K Henderson, and
R M Anderson
January 1972,
The Quarterly journal of medicine,
