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We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
October 1998,
Genomics,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
January 1988,
Cytogenetics and cell genetics,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
December 1982,
Proceedings of the National Academy of Sciences of the United States of America,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
May 1985,
Proceedings of the National Academy of Sciences of the United States of America,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
July 1985,
Proceedings of the National Academy of Sciences of the United States of America,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
January 1987,
Cytogenetics and cell genetics,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
December 1987,
Thrombosis and haemostasis,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
January 1997,
Cytogenetics and cell genetics,
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
August 1979,
Science (New York, N.Y.),
B G Neel, and
S C Jhanwar, and
R S Chaganti, and
W S Hayward
July 1988,
Nucleic acids research,
