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In a 3-year clinical trial, the caries prophylactic effect of two dentifrices containing 1000 ppm F and one containing 250 ppm F was compared. 541 twelve and thirteen-year-old children took part in the study. The children were randomly divided into three groups. Each group of children and their families used one of the dentifrices daily at home. The children were examined for caries at the start of the study and again after an interval of one year. The caries increment was equal in the three groups during the experimental period. This indicates that a 250 ppm F dentifrice has the same caries preventive effect as a 1000 ppm F dentifrice.
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