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Daily subcutaneous injections of 5 to 10 million units of partially purified human leukocyte interferon were given to newborn rabbits for 2 weeks or 1 month. The control groups received mock interferon, saline or nothing. The interferon treatment had no overt effect on the development of the animals during the period of treatment. The rabbits treated with interferon had leukocytosis, splenomegaly and prolonged postnatal extramedullary hematopoiesis in the liver and spleen. Certain immune responses were also demonstrated in the rabbits treated with interferon and mock interferon preparations. Platelet counts and the serum-ASAT, -ALAT, -LD and alkaline phosphatase values were normal.
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
January 1983,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
January 1990,
Developmental pharmacology and therapeutics,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
January 1980,
Journal of clinical microbiology,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
October 1981,
Mutation research,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
June 1986,
The Journal of urology,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
January 1967,
Annales medicinae experimentalis et biologiae Fenniae,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
June 1976,
The Journal of infectious diseases,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
January 1964,
Folia biologica,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
November 1973,
Lijecnicki vjesnik,
L Pyhälä, and
E Rimaila-Pärnänen, and
R Kekomäki, and
E Kostiainen, and
K Cantell
November 1973,
Harefuah,
