BIOMAT Database Logo BIOMAT Database Logo

[Clinical management of acute lymphocytic leukemia in adults. 1. Treatment of acute lymphocytic leukemia with VP (vincristine, prednisolone)--DVMP (daunorubicin, vincristine 6-mercaptopurine, prednisolone) regimen]. 1982

I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu

Eighteen patients with acute lymphocytic leukemia (ALL) were treated with VP (vincristine, prednisolone) followed by DVMP (daunorubicin + vincristine + 6-mercaptopurine + prednisolone) regimen (VP-DVMP regimen). Patients were all previously untreated. Complete remission (CR) was obtained in 11 of 18 patients (61.1%,) by VP alone and 4 patients, by VP-DVMP. The time required for CR varied from 14 to 60 days with a median of 28 days. The duration of CR and survivals in responders were from 1.2 to 42.3 + months with a median of 24.0 months. The hematological toxicities in VP-DVMP regimen were lower than those in NVP (neocarzinostatin + vincristine + prednisolone) and NVMP (neocarzinostatin + vincristine + 6-mercaptopurine + prednisolone) regimens.

UI MeSH Term Description Entries
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D003630 Daunorubicin A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. Daunomycin,Rubidomycin,Rubomycin,Cerubidine,Dauno-Rubidomycine,Daunoblastin,Daunoblastine,Daunorubicin Hydrochloride,NSC-82151,Dauno Rubidomycine,Hydrochloride, Daunorubicin,NSC 82151,NSC82151
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Daunorubicin, cytosine arabinoside, 6-mercaptopurine riboside, and prednisolone (DCMP) combination chemotherapy for acute myelogenous leukemia in adults.
December 1975, Cancer,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia.
July 1975, Cancer,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.
November 1975, Cancer,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
[Treatment of adult acute leukemia with a combination of cytosine arabinoside, vincristine, 6-mercaptopurine, prednisolone, and L-asparaginase (author's transl)].
November 1974, [Rinsho ketsueki] The Japanese journal of clinical hematology,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
A randomized clinical trial of daunorubicin and a combination of prednisone, vincristine, 6-mercaptopurine, and methotrexate in adult acute nonlymphocytic leukemia.
October 1972, Cancer research,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
[Remission induction with vincristine and prednisolone alone in adult acute lymphocytic leukemia].
September 1984, [Rinsho ketsueki] The Japanese journal of clinical hematology,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Comparison of prednisolone, vincristine, methotrexate and 6-mercaptopurine vs. 6-mercaptopurine and prednisone maintenance therapy in childhood acute leukemia: a Southwest Oncology Group Study.
September 1980, Cancer,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia.
June 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
Treatment of acute myelocytic leukemia with a daunorubicin-cytarabine-6 thioguanine regimen without maintenance therapy.
June 1985, Onkologie,
I Takahashi, and K Uchida, and E Ohmoto, and H Endo, and Y Oda, and S Fujimoto, and M Hara, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
[Treatment of childhood acute non-lymphocytic leukemia with the AVC regimen (adriamycin, vincristine and cytosine arabinoside)].
September 1987, [Rinsho ketsueki] The Japanese journal of clinical hematology,
Copied contents to your clipboard!