[Comparative evaluation of a combination of daunorubicin and cytosine arabinoside and that of aclarubicin and cytosine arabinoside in remission induction in acute non-lymphocytic leukemia]. 1982

I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu

A comparative trial of a combination of daunorubicin and cytosine arabinoside (Regimen A) and a combination of aclarubicin and cytosine arabinoside (Regimen B) was performed. Sixteen patients with acute non-lymphocytic leukemia, previously untreated, were entered into this study. Five of 8 patients (62.5%) obtained a complete remission (CR) in Regimen A and B, respectively. The days required for achieving a CR varied from 37 to 46 days in Regimen A and from 22 to 56 days in Regimen B. The total doses of daunorubicin and cytosine arabinoside were from 100 to 240 mg and from 640 to 1,120 mg in Regimen A, respectively. Those of aclarubicin were from 180 to 300 mg and from 660 to 1,000 mg in cytosine arabinoside in Regimen B. In a comparative study on hematological changes, toxic effects on peripheral white blood cell, platelet and nucleated cell counts in bone marrow tended to appear later in Regimen B compared to those in Regimen A. Side effects on digestive system such as nausea and vomiting and vascular pain were more frequently recognized in patients treated with Regimen B, although they were managed by symptomatic treatment. The results indicated the usefullness of aclarubicin in combination chemotherapy for the treatment of acute non-lymphocytic leukemia.

UI MeSH Term Description Entries
D007938 Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) Leucocythaemia,Leucocythemia,Leucocythaemias,Leucocythemias,Leukemias
D007948 Leukemia, Monocytic, Acute An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES. Leukemia, Monoblastic, Acute,Leukemia, Myeloid, Acute, M5,Leukemia, Myeloid, Schilling-Type,Monoblastic Leukemia, Acute,Monocytic Leukemia, Acute,Myeloid Leukemia, Acute, M5,Myeloid Leukemia, Schilling-Type,Leukemia, Acute Monocytic,Leukemia, Myeloid, Schilling Type,Acute Monoblastic Leukemia,Acute Monoblastic Leukemias,Acute Monocytic Leukemia,Acute Monocytic Leukemias,Leukemia, Schilling-Type Myeloid,Leukemias, Acute Monoblastic,Leukemias, Acute Monocytic,Monoblastic Leukemias, Acute,Monocytic Leukemias, Acute,Myeloid Leukemia, Schilling Type,Schilling-Type Myeloid Leukemia
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009279 Naphthacenes Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES. Tetracenes,Benz(b)Anthracenes
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D003561 Cytarabine A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472) Ara-C,Arabinofuranosylcytosine,Arabinosylcytosine,Cytosine Arabinoside,Aracytidine,Aracytine,Cytarabine Hydrochloride,Cytonal,Cytosar,Cytosar-U,beta-Ara C,Ara C,Arabinoside, Cytosine,Cytosar U,beta Ara C
D003630 Daunorubicin A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. Daunomycin,Rubidomycin,Rubomycin,Cerubidine,Dauno-Rubidomycine,Daunoblastin,Daunoblastine,Daunorubicin Hydrochloride,NSC-82151,Dauno Rubidomycine,Hydrochloride, Daunorubicin,NSC 82151,NSC82151
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug

Related Publications

I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
January 1979, Leukemia research,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
January 1989, Medical and pediatric oncology,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
April 1989, The American journal of medicine,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
January 1994, Cancer chemotherapy and pharmacology,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
April 1973, Cancer,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
July 1975, Minerva medica,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
July 1981, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
February 1984, European journal of cancer & clinical oncology,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
January 1979, Cancer treatment reports,
I Takahashi, and M Hara, and E Ohmoto, and Y Oda, and Y Endo, and S Fujimoto, and K Uchida, and K Takaoka, and S Watanabe, and M Lai, and F Kohi, and K Kitajima, and I Kimura, and H Sanada, and M Tokioka, and T Adachi, and S Yorimitsu
January 1974, Bulletin du cancer,
Copied contents to your clipboard!