BIOMAT Database Logo BIOMAT Database Logo

Immunologic evaluation in mycosis fungoides. Before and after PUVA therapy. 1980

R Kubba, and P L Bailin, and H H Roenigk

Eight patients with mycosis fungoides (seven in plaque stage and one with tumors) were successfully treated with methoxalen-ultraviolet-A (PUVA) photochemotherapy. A selective immunity evaluation had been carried out prior to starting treatment and was repeated sevedn to 33 months (mean, 22 months) later. The results of pre-PUVA and post-PUVA therapy evaluation were compared. The delayed hypersensitivity responses improved in all eight patients, and four patients who were anergic before treatment manifested a normal response after PUVA therapy. The T lymphocyte counts were reduced in four patients before PUVA therapy (mean +/- SD, 66.72% +/- 9.78%) and in seven patients after PUVA (mean +/- SD, 54.43% +/- 10.86%; P = .03). The results of mitogen stimulation studies with phytohemagglutinin, pokeweed mitogen, and concanavalin A were equivocal. The levels of serum immunoglobulins were not affected. One patient had a positive antinuclear factor test of low titer.

UI MeSH Term Description Entries
D007111 Immunity, Cellular Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role. Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D007136 Immunoglobulins Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008297 Male Males
D008730 Methoxsalen A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation. 8-Methoxypsoralen,Ammoidin,Xanthotoxin,8-MOP,Deltasoralen,Dermox,Geroxalen,Meladinina,Meladinine,Meloxine,Methoxa-Dome,Méladinine,Oxsoralen,Oxsoralen-Ultra,Puvalen,Ultramop,8 MOP,8 Methoxypsoralen,8MOP,Methoxa Dome,Oxsoralen Ultra
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009182 Mycosis Fungoides A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R Kubba, and P L Bailin, and H H Roenigk
Bcl-2 expression in mycosis fungoides before and after PUVA therapy.
April 2010, Photodermatology, photoimmunology & photomedicine,
R Kubba, and P L Bailin, and H H Roenigk
Follicular mycosis fungoides--augmentation by PUVA therapy.
March 1995, Acta dermato-venereologica,
R Kubba, and P L Bailin, and H H Roenigk
Nitrogen mustard and PUVA therapy of mycosis fungoides.
November 1981, Clinical and experimental dermatology,
R Kubba, and P L Bailin, and H H Roenigk
[Interferon-alpha and PUVA therapy for mycosis fungoides].
September 2001, Orvosi hetilap,
R Kubba, and P L Bailin, and H H Roenigk
PUVA treatment in mycosis fungoides.
January 1979, Dermatologica,
R Kubba, and P L Bailin, and H H Roenigk
[Granulomatous mycosis fungoides: combination therapy with bexarotene and PUVA].
April 2014, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
R Kubba, and P L Bailin, and H H Roenigk
PUVA therapy and narrowband UVB therapy in Tunisian patients with mycosis fungoides.
January 2009, Therapie,
R Kubba, and P L Bailin, and H H Roenigk
Puva-Sol therapy at the Dead Sea in mycosis fungoides.
June 1983, Dermatologica,
R Kubba, and P L Bailin, and H H Roenigk
Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.
January 2005, Acta dermato-venereologica,
R Kubba, and P L Bailin, and H H Roenigk
PUVA treatment of mycosis fungoides [proceedings].
January 1978, Dermatologica,
Copied contents to your clipboard!