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Patients who underwent operations in which cardiopulmonary bypass was used had elevations of plasma fibrinopeptide A which did not return to normal during bypass despite conventional heparin anticoagulation, suggesting inadequate heparin dosage and continued thrombin activity during the operation. Patients who underwent aortocoronary artery grafting had high plasma thromboxane B2 levels and a rapid fall in platelet count at the onset of extracorporeal circulation. Thromboxane elevations were less marked in patients who underwent valve replacement. Platelet aggregation and coronary artery constriction secondary to thromboxane production may contribute to the morbidity of cardiopulmonary bypass.
G C Davies, and
M Sobel, and
E W Salzman
June 1985,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
G C Davies, and
M Sobel, and
E W Salzman
January 1978,
Surgical forum,
G C Davies, and
M Sobel, and
E W Salzman
June 1986,
The Journal of thoracic and cardiovascular surgery,
G C Davies, and
M Sobel, and
E W Salzman
March 1981,
Journal of periodontal research,
G C Davies, and
M Sobel, and
E W Salzman
January 1992,
Eicosanoids,
G C Davies, and
M Sobel, and
E W Salzman
January 1997,
Journal of investigative surgery : the official journal of the Academy of Surgical Research,
G C Davies, and
M Sobel, and
E W Salzman
November 1990,
Journal of applied physiology (Bethesda, Md. : 1985),
G C Davies, and
M Sobel, and
E W Salzman
January 1981,
Paroi arterielle,
G C Davies, and
M Sobel, and
E W Salzman
March 1995,
The Annals of thoracic surgery,
G C Davies, and
M Sobel, and
E W Salzman
August 1989,
Prostaglandins, leukotrienes, and essential fatty acids,
