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Three cell wall fractions, prepared from Micropolyspora faeni, were shown to be mitogenic for the splenic lymphocytes of unsensitized guinea pigs. This response peaked after 48 hr in culture and was dose dependent. Using enriched lymphocyte subpopulations obtained by column-separation techniques, it was shown that the most active cell wall fractions were primarily B cell mitogens. Physical, chemical, and enzymatic digestion studies indicated that the heat-stable mitogenic reactivity was associated with polypeptide and polysaccharide. The reactive material is, at least in part, peptidoglycan, as shown by the decrease in its mitogenic potential after lysozyme digestion. A possible host-related role for this mitogenic reactivity was discussed.
S M Smith, and
I S Snyder, and
R Burrell
December 1983,
The American review of respiratory disease,
S M Smith, and
I S Snyder, and
R Burrell
October 1984,
American journal of veterinary research,
S M Smith, and
I S Snyder, and
R Burrell
January 1994,
American journal of industrial medicine,
S M Smith, and
I S Snyder, and
R Burrell
April 1978,
The Journal of allergy and clinical immunology,
S M Smith, and
I S Snyder, and
R Burrell
November 1981,
Infection and immunity,
S M Smith, and
I S Snyder, and
R Burrell
January 1979,
International archives of allergy and applied immunology,
S M Smith, and
I S Snyder, and
R Burrell
January 1977,
International archives of allergy and applied immunology,
S M Smith, and
I S Snyder, and
R Burrell
September 1975,
Research in veterinary science,
S M Smith, and
I S Snyder, and
R Burrell
February 1976,
Chest,
S M Smith, and
I S Snyder, and
R Burrell
August 1988,
The Journal of allergy and clinical immunology,
