BIOMAT Database Logo BIOMAT Database Logo

Lipopolysaccharide (LPS) regulation of the immune response: T lymphocytes from normal mice suppress mitogenic and immunogenic responses to LPS. 1980

J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen

UI MeSH Term Description Entries
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008819 Mice, Nude Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D008934 Mitogens Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed) Mitogen,Phytomitogen,Phytomitogens
D010581 Peyer's Patches Lymphoid tissue on the mucosa of the small intestine. Patches, Peyer's,Peyer Patches,Peyers Patches
D010835 Phytohemagglutinins Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture. Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D005856 Germ-Free Life Animals not contaminated by or associated with any foreign organisms. Axenic Animals,Gnotobiotics,Germfree Life,Animal, Axenic,Animals, Axenic,Axenic Animal,Germ Free Life,Gnotobiotic,Life, Germ-Free,Life, Germfree

Related Publications

J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Mitogenic responses of frog lymphocytes to crude and purified preparations of bacterial lipopolysaccharide (LPS).
January 1983, Developmental and comparative immunology,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
LPS regulation of the immune response: Bacteroides endotoxin induces mitogenic, polyclonal, and antibody responses in classical LPS responsive but not C3H/HeJ mice.
July 1984, Journal of immunology (Baltimore, Md. : 1950),
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Effect of lipopolysaccharide (LPS) injection on the immune responses of LPS-sensitive mice.
October 2004, The Journal of veterinary medical science,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities.
February 1975, Journal of immunology (Baltimore, Md. : 1950),
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Mitogenic responses to lipopolysaccharide by B lymphocytes from patients with systemic lupus erythematosus.
May 1981, Scandinavian journal of immunology,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Mitogenic responses of sheep peripheral blood T-lymphocytes to PHA and LPS in a hanging drop microassay.
January 1984, Acta veterinaria Scandinavica,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
IBDV-induced bursal T lymphocytes inhibit mitogenic response of normal splenocytes.
April 2000, Veterinary immunology and immunopathology,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
[Normal and abnormal regulation of human T lymphocytes in immune response (author's transl)].
September 1978, Nihon Kyobu Shikkan Gakkai zasshi,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Mitogenic responses of splenic B and T lymphocytes in neonatally capsaicin-treated mice.
January 1986, International archives of allergy and applied immunology,
J R McGhee, and H Kiyono, and S M Michalek, and J L Babb, and D L Rosenstreich, and S E Mergenhagen
Mitogenic response of T-lymphocytes to exercise training and stress.
June 1991, Journal of applied physiology (Bethesda, Md. : 1985),
Copied contents to your clipboard!