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The behavioural syndrome caused by L-5-HTP in rats was used for the study of effects of selective 5-HT uptake inhibitors and inhibitors of MAO on central 5-HT receptors. A good correlation was found between the relative potencies of drugs in inhibiting the 5-HT uptake in the rat brain and in intensifying L-5-HTP-induced behavioural stimulation. The potentiation of the L-5-HTP syndrome by the MAO inhibitors correlated with the inhibition of the A- but not of the B-form of the brain monoamine oxidase. In rats treated with the maximally inhibiting dose of a 5-HT uptake inhibitor, MAO inhibitors were still able to increase the intensity of the L-5-HTP syndrome, while the combination of maximal doses of two 5-HT uptake inhibitors did not produce a more intense syndrome than that produced by one 5-HT uptake inhibitor alone. The L-5-HTP-induced behavioural syndrome in rats seems to afford an experimental model allowing the quantification and characterization of the interaction of drugs with serotonin metabolism in the brain.
R Ortmann, and
P C Waldmeier, and
E Radeke, and
A Felner, and
A Delini-Stula
April 1990,
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R Ortmann, and
P C Waldmeier, and
E Radeke, and
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A Delini-Stula
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R Ortmann, and
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January 1971,
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P C Waldmeier, and
E Radeke, and
A Felner, and
A Delini-Stula
March 1968,
Life sciences,
R Ortmann, and
P C Waldmeier, and
E Radeke, and
A Felner, and
A Delini-Stula
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R Ortmann, and
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E Radeke, and
A Felner, and
A Delini-Stula
August 1981,
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R Ortmann, and
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A Felner, and
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August 1988,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
